Post by Admin on Nov 18, 2020 3:28:53 GMT
Moa (Mechanism of Action)
Imiquimod enhances both the innate and the acquired immune systems and thereby stimulates a response against abnormal skin cells, which are then eliminated through the body's own mechanisms.
Imiquimod exerts its actions through the following sequence of events: ▴
Binding to Toll-like receptors on B cells
Increased release of inflammatory mediators, including interferon, TNF, and many interleukins: IL-1, IL-6, IL-8, and IL-10
Increased immune cell activity: •
Activating macrophages and Langerhans cells
Inducing proliferation and maturation of B lymphocytes
Increasing natural killer T cell activity
Imiquimod also has direct apoptosis activity with tumor cells.
The net effect of applying topical imiquimod to the skin is an increased inflammatory reaction in the dermis, and through this reaction, abnormal cells are destroyed in the heightened inflammatory environment.
Use imiquimod on suitable SK lesions on the face and scalp
Imiquimod has not been evaluated for treatment on the eyelids, the inside of the nostrils, ears, or the lip area inside the vermillion border and there are insufficient data to support the use of imiquimod on the hands and forearms. imiquimod cream over the counter Imiquimod is not recommended for the treatment of SK lesions when there is marked hyperkeratosis or hypertrophy.2
Patients Being Treated for Superficial Basal Cell Carcinoma (sBCC)
Dosing is 5 times per week for a full 6 weeks, unless otherwise directed by the physician. healthquestions.medhelp.org/aldara-molluscum-contagiosum-children However, the treatment period should not be extended beyond 6 weeks due to missed doses or rest periods .
It is recommended that the treatment area be washed with mild soap and water 8 hours following Aldara Cream application .
Most patients using Aldara Cream for the treatment of sBCC experience erythema, edema, induration, erosion, scabbing/crusting and flaking/scaling at the application site with normal dosing .
Use of sunscreen is encouraged, and patients should minimize or avoid exposure to natural or artificial sunlight (tanning beds or UVA/B treatment) while using Aldara Cream .
The clinical outcome of therapy can be determined after resolution of application site reactions and/or local skin reactions.
Patients with sBCC treated with Aldara Cream should have regular follow-up to re-evaluate the treatment site .
Abstract
Objective: Since imiquimod, a nucleoside analogue of the imidazoquinoline family, has shown efficacy against many tumour entities, its mode of action has become a focus of scientific interest.
Results: The major biologic effects of imiquimod are mediated through agonistic activity towards toll-like receptors (TLR) 7 and 8, and consecutively, activation of nuclear factor-kappa B (NF-kappaB). click here The result of this activity is the induction of pro-inflammatory cytokines, chemokines and other mediators leading to activation of antigen-presenting cells and other components of innate immunity and, eventually, the mounting of a profound T-helper (Th1)-weighted antitumoral cellular immune response. Several secondary effects on the molecular and cellular level may also be explained, at least in part, by the activation of NF-kappaB. Moreover, independent of TLR-7 and TLR-8, imiquimod appears to interfere with adenosine receptor signalling pathways, and the compound causes receptor-independent reduction of adenylyl cyclase activity. This novel mechanism may augment the pro-inflammatory activity of the compound through suppression of a negative regulatory feedback mechanism which normally limits inflammatory responses. Finally, imiquimod induces apoptosis of tumour cells at higher concentrations. The pro-apoptotic activity of imiquimod involves caspase activation and appears to depend on B cell lymphoma/leukemia protein (Bcl)-2 proteins.
Conclusions: Overall, imiquimod acts on several levels, which appear to synergistically underlie the profound antitumoral activity of the compound.
How do I store and/or throw out Aldara?
- [*]Store at room temperature. Do not freeze.[*]Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.[*]Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Ingredients
Each 250mg of Aldara cream 5% contains 12.5mg of the active ingredient, imiquimod. wikimili.com/en/Imiquimod Aldara cream also contains isostearic acid, benzyl alcohol, cetyl alcohol, stearyl alcohol, white soft paraffin, polysorbate 60, sorbitan monostearate, glycerol, methyl hydroxybenzoate, propyl hydroxybenzoate, xanthan gum, purified water.